Articles Tagged With:
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The Association Between SSRIs and Congenital Anomalies
In this synthesis involving 15 meta-analytic studies, four studies demonstrated an association between paroxetine use during pregnancy and increased risk of major congenital anomalies (relative risk [RR], 1.18 [95% confidence interval (CI), 1.05, 1.32] to 1.29 [95% CI, 1.11-1.49]). For all selective serotonin reuptake inhibitors (SSRIs), the RR for major anomalies (1.10 [95% CI, 1.03, 1.16] to 1.27 [95% CI, 1.09, 1.47]) and cardiac defects (1.06 [95% CI, 0.94, 1.18] to 1.36 [95% CI, 0.61, 3.04]) were increased. This meta-analysis suggests an increased risk of cardiac and major anomalies with SSRI use, but the results should be interpreted with caution, since all included studies were meta-analyses of retrospective cohort studies.
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Management of Heavy Menstrual Bleeding: Levonorgestrel-Releasing Intrauterine System vs. Endometrial Ablation
In this multicenter, randomized, noninferiority trial among patients aged 34 years and older with heavy menstrual bleeding, the levonorgestrel-releasing intrauterine system did not meet the noninferiority threshold when compared to endometrial ablation for mean blood loss at 24 months following intervention. Both interventions did lead to large decreases in blood loss and comparable satisfaction and quality-of-life scores.
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Throat Infections Part I: Low-Acuity Disease Entities
Sore throats are common! Being able to differentiate low-acuity self-limited infections from those processes that may result in sepsis or life-threatening airway compromise is critical. The author, in this two-part article, reviews the range of pathologies that may present with a sore throat. -
Ethical Obstacles When Securing Informed Consent for ICU Research
Usually, there is plenty of time for patients or families to decide if they want to be involved in a clinical trial, and there is adequate time for a thorough informed consent process. It’s a bit different in the ICU. -
Intensity of Treatment Is Common Issue in Consults for Solid Organ Transplant
Ethical questions on organ transplantation have focused mainly on resource allocation — access to transplantation and prioritization of donor organs. A recent analysis revealed few consults were called for questions about appropriate resource allocation. -
The Unique Characteristics of Surgical Consults
Ethics consults called by surgical specialties differ somewhat from consults called by other hospital specialties. -
Chaplains Report Receiving No Ethics Education
Chaplains often serve on ethics committees, as ethics consultants, and as institutional review board members. Yet there are no standardized ethics curricula in Clinical Pastoral Education programs. -
Fewer Family Meetings in ICU Are Reason for Dissatisfaction
Supporting families faced with making critical decisions for incapacitated loved ones is a core ethical duty for ICU clinicians. Yet little is known about family characteristics that predict their dissatisfaction with support during decision-making. -
Ethics Tries to Keep Up with Quickly Evolving Stem Cell Research
Updated guidelines offer specific recommendations for embryo research, stem cell embryo models, organoids, chimeras, germline genome editing, and mitochondrial replacement techniques. Public support for controversial research is an overarching goal. -
Some Consults Specifically Address Moral Distress
A Virginia-based health system has learned much about moral distress and why it is important to recognize and intervene.